Most frequently, it is observed as a unilateral lesion involving the foot or leg, although bilateral lesions as well as multiple lesions have been reported; other regions such as the trunk Bacterial infections are uncommon. Osteomyelitis has been associated with bullosis diabeticorum. What is the Evidence? Larsen, K, Jensen, T, Karlsmark, T, Holstein, PE. “Incidence of bullosis diabeticorum – a controversial cause of chronic foot ulceration”.

Bullosis diabeticorum causes

Bullosis diabeticorum: a distinctive blistering eruption in diabetes mellitus. Int J Diabetes Dev Ctries 29(1): 41-42. 4. Larsen K, Jensen T, Karlsmark T, Holstein PE (2008) Incidence of bullosis diabeticorum—a controversial cause of chronic foot ulceration. International Wound Journal 5(4): 591-596. 5.

Hard, thickening skin. Blisters.

Larsen, K, Jensen, T, Karlsmark, T, Holstein, PE. “Incidence of bullosis diabeticorum – a controversial cause of chronic foot ulceration”. Int Wound J. vol. 5. 2008.

591-6.
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While this disease is unique to patients with diabetes, it may mimic other blistering disorders.

Also known as diabetic blisters, this skin problem can occur on the back of the fingers, hands, toes, feet, and sometimes on the legs or forearms. These blisters may occur alone or in patches and resemble burn blisters. However, they are not very painful. The exact cause of diabetic blisters is unclear, but several factors might play a role in their development.
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Bullosis diabeticorum: case report and review. Angela J Zhang, Michele Garret, Steven Miller.